Abstract: Objective To evaluate the safety and curative effects of laparoscopic -assisted right hemicolectomy for right colon cancer via the approach of small mesentery root. Methods Technique of laparoscopic right hemicolectomy was performed in 20 patients with right colon cancer in our hospital from January 2014 to January 2016. Of the 20 cases, there were 15 males and 5 females with age ranging from 32-70 years (average age: 52 years). Results The operations to 20 cases were completely finished without conversion to open surgery with a median operating time of 60 min (range: 55 -70 min). The total number of resected lymph nodes was 12-25 (mean number of 18), and the volume of intraoperative blood loss was 15-50 ml (mean: 30 ml). The auxiliary incision was 5 cm long on average, and the median hospital stay was 7 days. No complications were found in this series. The classification in TNM stage after the operation included 5 cases of Ⅱ A, 10 cases of Ⅱ B, and 5 cases of Ⅲ A stage. The postoperative pathological results were 6 cases with poorly differentiated adenocarcinoma, 12 cases with medium differentiated adenocarcinoma and 2 with mucinous adenocarcinoma. Conclusion The combination of open and laparoscopic surgery via the approach of the small mesentery root makes laparoscopic right hemicolectomy more easily to be mastered.