Abstract: Objective To evaluate the clinical, endoscopic, and pathological characteristics related to complications of endoscopic papillectomy (EP) for duodenal papilla lesion. Methods The endoscopic and clinical data about 106 cases with duodenal papilla lesion who received EP in Chinese PLA General Hospital from January 2007 to March 2017 were retrospectively analyzed. Of the 106 cases, there were 70 males and 36 females with average age of (58.8±12.5) years (ranging from 23 to 87 years), and they were divided into two groups according to with or without complications. Results Complications occurred in 37 cases with complication rate of 34.90%. There were 19 patients with acute pancreatitis (17.92%), 25 patients with hemorrhage (23.58%), 8 patients with acute cholangitis (7.55%), and 3 patients with perforation (2.83%). The complication occurrence was related to tumor size and en bloc resection, but it was not related to gender, age and final pathology results, complete resection, submucosal injection, endoscopic sphincterotomy and placement of stents. Conclusion The incidence of EP complications is related to tumor diameter and en bloc resection, and it increases when tumor diameters are greater than 3.0 cm or the operation is en bloc resection.