Abstract: Objective To investigate the effect of delayed perforator-based sural neurofasciocutaneous flap on repair of midfoot and forefoot wound． Methods A retrospective study of 41 cases (aged from 45 to 65 years old) with midfoot and forefoot injury from May 2005 to July 2015 was performed． Of the 41 cases, 19 cases underwent delayed perforator-based sural neurofasciocutaneous flap repair on wounds, and the other 22 cases with direct perforator-based sural neurofasciocutaneous flap repair． Operation indexes of patients in two groups were compared postoperatively． Results No significant difference was found in general data between two groups． The number of flaps that still needed secondary operation or long-term dressing change were 2/19 and 10/22 with significant differences between two groups (P=0．014)． The excellent rates after six months were 84．21% and 81．82% with no significant difference (P=0．59)． Conclusion As for the short-term effect, delayed perforator-based sural neurofasciocutaneous flap for repair of midfoot and forefoot wound is better than direct perforator-based sural neurofasciocutaneous flap, which can shorten hospital stay and reduce the risk of secondary operation．