Abstract: The intraosseous (IO) infusion route can be established fast when intravenous (IV) route is not accessible or central venous catheterization is too time-consuming or peripheral vascular collapses, and the IO access has been recommended by several resuscitation guidelines． Besides, quickly achieved IO route can minimize the effects to interruption of chest compressions． The userfriendly designed IO infusion gun makes it an attractive alternation of resuscitation． In this study, we review the application of IO infusion during cardiopulmonary resuscitation (CPR) and the development of IO infusion guns, which may promote the domestic popularization and understanding of its advantages and disadvantages in the life-saving procedure．