Abstract: Objective To observe the clinical effect of Qushi Liangxue Decoction in treatment of chronic eczema. Methods A total of 120 patients with chronic eczema were randomly divided into two groups: treatment group (n=60) and western medicine control group (n=60). Two cases in treatment group and one case in control group dropped out. Patients in treatment group were treated with Qushi Liangxue Decoction for one dose twice a day and the control group was treated with compound ointment twice a day. Both two groups were treated for 4 weeks. EASI, VAS score, total effective rate and recurrence rate were compared before and after treatment. Results After 4 weeks of treatment, the EASI and side effect rate in the treatment group were lower than those in the control group with no significant difference 1.40 (1.98) vs 1.60 (2.00), 3.45% vs 10.17%; P> 0.05, respectively. The total effective rate in the treatment group was higher than that in the control group with no significant difference (87.9% vs 79.6%, P> 0.05). The VAS score and the recurrence rate in the treatment group were significantly lower than those in the control group with significant difference2.00 (4.00) vs 5.00 (5.00), 10.3% vs 25.4%; P< 0.05, respectively. Conclusion Qushi Liangxue Decoction is effective and safe in treating patients with chronic eczema, with less recurrence.