Abstract: Objective To investigate the short-term effect of CAD/CAM CEREC Blocs restorations and its failure modes. Methods Total of 142 cases (193 CEREC Blocs) who had undergone CEREC CAD/CAM Blocs restorations in Qianfoshan Hospital from March 2013 to May 2016 were followed up. According to the modified United States public health service (USPHS), the clinical performance of the restoration were evaluated and its failure modes were analyzed. The cumulative survival rate of all-ceramic restoration, type and position of fixed prostheses, and the influence of dowel core on survival rate of fixed prostheses were analyzed by Kaplan-Meier survival analysis. Results During the observation period of 7-39 months, two restorations fell off completely, four restorations partially broken, and another two restorations cracked but remained intact. The cumulative survival rate of 193 CEREC Blocs restorations was 93.2%, the survival rates of restorations of different types and different positions showed no significant difference (All P> 0.05), and there was no significant difference in the survival rate between with dowel core group and without dowel core group (P> 0.05). Conclusion CEREC CAD/CAM Blocs may achieve good restoration effect in short term, while there is no significant difference in the survival rate between with dowel core group and without dowel core group.