Abstract: Objective To assess the efficacy of low-level laser therapy (LLLT) for patients with erosive oral lichen planus. Methods A total of 30 patients with two separate erosions in each person were included in this study from January 2016 to October 2017. The lesions were randomly assigned into active treatment group or sham control group for each patient. Lesions assigned to active group were treated with LLLT in a single sitting, which was divided into four sessions with 45 s as a session. Lesions in the sham control group received similar treatment without LLLT. Each patient was evaluated for pain, lesion size, and time to complete healing before and after each treatment. Results The average healing time of ulcers in treatment group was (3.05±1.10) days, significantly lower than (8.90±2.45) days in the control group (P=0.008); Of the 30 patients in the experimental group, 28 experienced immediate pain relief after first treatment. VAS was significantly lower, and the lesion size was significantly smaller in treatment group (all P< 0.05). Conclusion LLLT is effective in relieving pain and reducing healing time in treatment of oral lichen planus.