Abstract: Objective To observe the effect of partial vaginal closure in the treatment of severe pelvic organ prolapse. Methods Fiftysix patients with severe pelvic organ prolapse admitted to our hospital from January 2016 to January 2017 were enrolled in our study.According to the patients’ choice of surgical methods, they were divided into vaginal closure group (n=20) and traditional surgery group (n=36). The effect of transvaginal reconstruction of pelvic floor and partial closure of vagina were observed and compared. Results The intraoperative blood loss (204.65±20.36) ml vs (294.65±30.29) ml, operating time (1.21±0.25) h vs (1.76±0.14) h, time of getting out of bed after operation (1.52±0.58) d vs (2.01±0.64) d and hospital stay (7.25±1.36) d vs (9.25±1.24) d in the vaginal closure group were significantly lower or shorter than those in traditional operation group (all P< 0.05). There was no significant difference in PFDI-20 and PFIQ-7 scores between the two groups before operation (P> 0.05). After 1 year of followup, the scores of the two groups improved significantly, and the improvement was greater in vaginal closure group compared with traditional surgery group (4.25±1.02 vs 7.25±1.59, P=0.000; 44.92±19.36 vs 57.25±18.25, P=0.038). The total effective rate of vaginal closure group was 95.00%, which was significantly higher than the traditional operation group (69.44%) (P=0.000). Conclusion Compared with traditional surgery, partial closure of vagina is more helpful for pelvic floor function recovery, improving therapeutic effect and long-term prognosis of patients, which is worthy of clinical application.