Abstract: Objective To study the effect of Shenxiong glucose injection combined with Tora Semide in the treatment of heart failure and its effect on hemorheology, the level of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-crp). Methods Eighty patients were selected in our hospital from October 2017 to April 2018, and they were randomly divided into the treatment group (n=40) and the control group (n=40). Angiotensin converting enzyme inhibitor(ACEI), cardiotonic drugs, vasodilator, beta blocker, aldosterone receptor antagonist and other treatment were given to both two groups. On this basis, torasemide treatment was given to the control group, and the treatment group received intravenous infusion of Shenxiong glucose injection plus former treatment. After 4 weeks of treatment, the therapeutic effects of two groups were observed.The changes of hemorheology, hs-CRP and NT-proBNP levels and cardiac function in two groups before and after treatment and the incidence of adverse reactions in two groups during treatment were compared. Results After treatment, the total effective rate of the observation group was 92.50% (37/40), which was significantly higher than that of the control group (75.00%, 30/40) (P< 0.05).After treatment, the HCT, EEP, ESR and PV in the observation group were significantly lower than those in the control group HCT:24.54%±2.88% vs 32.47%±4.47%, EEP: (298.47±13.56) s vs (327.45±14.29) s, ESR: (18.66±4.85) mm/h vs (22.71±3.57) mm/h, PV: (1.19±0.37) mPa/s vs (1.76±0.27) mPa/s, all P< 0.05. The plasma hs-CRP and NT-proBNP levels in the observation group were significantly lower than those in the control group (P< 0.01), while the 6-min walking distance and LVEF in observation group were significantly higher than control group (P< 0.01). There was no significant difference in adverse reaction rate between two groups (P> 0.05). Conclusion Shenxiong glucose injection combined with torasemide can be used in treatment of heart failure by improving the hemorheological index and cardiac function index, which is safe and reliable.