Abstract: Objective To explore the safety and feasibility of early oral feeding after 3D laparoscopic radical total gastrectomy for patients with gastric cancer. Methods Clinical and pathological data about 134 patients who underwent 3D laparoscopic radical total gastrectomy in department of general surgery, Chinese PLA General Hospital from March 2017 to March 2018 were analyzed retrospectively. Cases were divided into early oral feeding group and routine feeding group and matched by sex, age, body mass index (BMI), TNM stage and tumor differentiation degree, with 67 in each group. Recovery time of gastrointestinal function, postoperative nutritional status, tolerance of oral feeding and postoperative complications were compared between the two groups. Results Compared with routine feeding group, patients in early oral feeding group had significantly shorter time to postoperative first flatus (2.66±1.38) d vs (3.37±1.19) d, P=0.000, time to first defecation (3.46±1.41) d vs (4.52±1.26) d, P=0.012, less postoperative hospitalization (6.51±1.53) d vs (8.62±1.48) d, P=0.000 and lower hospitalization expenses (1.74±0.51) thousand yuan vs (2.12±0.83) thousand yuan, P=0.012 . At 6 days after operation, serum prealbumin level (177.6±33.1) mg/L vs (149.4±25.3) mg/L, P=0.016 and serum albumin level (37.3±3.1) g/L vs (34.1±3.5) g/L, P=0.011 were higher in early oral feeding group. There was no significant difference in the incidence of postoperative complications between the two groups (all P> 0.05). Conclusion Early oral feeding after 3D laparoscopic radical gastrectomy can promote the recovery of gastrointestinal function, improve nutritional status, reduce length of hospital stay and hospital expenses and it does not increase the incidence of postoperative complications, which is safe and feasible for gastric cancer patients.