Abstract: Objective To explore the clinical feature and surgical treatment of obstructive sleep apnea hypopnea syndrome(OSAHS) in HIV/AIDS patients. Methods The etiology, clinical features, treatment and prognosis of 18 HIV/AIDS patients with OSAHS admitted to our hospital from January 2015 to April 2018 were retrospectively analyzed. Results Of the 18 cases, OSAHS was assessed as severe in 2 cases, moderate in 7 cases, and mild in 9 cases. The causes of disease included chronic tonsillitis, tonsil hypertrophy, deviation of nasal septum, hypertrophic rhinitis. After surgical treatment, the symptoms of OSAHS disappeared completely in 16 cases, and significantly improved in 2 cases. Before the surgery, the ESS score were (14.54±3.61)and (15.29±1.60) in tonsil disease group and nasal disease group, respectively, then it changed to (8.00±2.65), (7.00±1.91) in two groups after surgery, with significant differences compared to before surgery (all P＜ 0.05). Conclusion With definitive diagnosis and strict control of surgical indication, individualized surgical treatment is effective to OSAHS for HIV/AIDS patients.