热射病中枢神经系统损伤及防治研究进展

Research advances in prevention of central nervous system injury of heat stroke

摘要: 热射病(heat stroke，HS)是指严重危及生命的致死性中暑，大多伴有中枢神经系统(central nervous system，CNS)功能损伤。高热、炎症反应、热应激等是导致CNS损伤的重要病理生理机制，也是导致HS患者死亡的主要原因。了解HS的CNS损伤的发病机制及其防治方法，有助于提高对HS疾病的认识，更好地指导临床救治，从而显著降低患者的死亡率。

Abstract: Heat stroke (HS) is a fatal heat-related illness, which is always associated with impairment of central nervous system(CNS). High fever, inflammatory response and heat stress are important pathophysiological mechanisms leading to CNS injury, and they are also the main causes of death of HS patients. Understanding the pathogenesis of CNS injury of HS is helpful to improve the understanding of HS disease and guide clinical treatment, so as to reduce its mortality.