Abstract: Objective To study the clinical characteristics of cryptococcal meningitis(CM), and provide further evidence for its clinical diagnosis and therapy. Methods Clinical data about inpatients with CM admitted to the department of neurology, the Fourth Medical Center of Chinese PLA General Hospital from January 2016 to December 2017 were collected, and their clinical manifestations, laboratory test results, cranial imaging examination, treatment and prognosis were analyzed retrospectively. Results There were 10 males and 5 females with age ranging from 26 to 87 years(average age of 54.53±15.92 years). Of the 15 cases, 8 patients had underlying diseases and 1 patient had contact history with pigeon, 12 patients had "fever, headache" as the first symptom. Intracranial hypertension occurred in 12 patients, and the intracranial pressure in 8 patients was higher than 300 mm H₂ O.Four patients underwent Ommaya cyst implantation. The misdiagnosis at the first visit occurred in 10 cases. The time to diagnosis ranged from 15 days to 3 months. All patients had positive results to incapsular antigen detection, while 7 cases had negative results to the first India ink stain. Voriconazole monotherapy was performed in 8 cases, Amphotericin B liposome + flucytosine combination therapy in 2 cases, voriconazole + amphotericin B liposome + flucytosine in 5 cases. One patient died and 14 patients were cured. Conclusion CM is easy to be misdiagnosed as tuberculosis or virus infection. The sensitivity of capsular antigen detection is high. Intracranial hypertension often occurs in patients with CM, while Ommaya capsule implantation treatment can alleviate the symptoms. Voriconazole is effective on CM, especially for elderly patients with multiple organ dysfunction and renal transplantation.