冠状动脉支架置入术患者血脂达标影响因素分析

Influencing factors of LDL-cholesterol goal attainment in patients after PCI

  • 摘要: 目的 评估冠状动脉支架置入术后患者的血脂达标率及影响因素。方法 分析2016年12月-2017年11月于荆州市第一人民医院行冠状动脉支架置入术的133例患者血脂低密度脂蛋白胆固醇达标情况,对血脂达标的影响因素行Logistic回归分析。结果 血脂达标组46例,其中男36例,女10例,平均年龄(61.74±7.09)岁;未达标组87例,男62例,女25例,平均年龄(62.11±9.22)岁。Logistic回归结果显示,长期他汀药物服用史(OR=0.43,P=0.005)、良好的药物依从性(OR=0.42,P=0.045)是血脂达标的保护因素,超重(OR=1.31,P=0.040)、日服药种类多(OR=3.70,P=0.001)为血脂达标的危险因素。术后西雅图心绞痛量表评分,血脂达标患者优于未达标组(P均<0.001)。结论 坚持长期服用他汀类药物、良好的药物依从性有利于调脂治疗达标;超重、日服药量多不利于有效调脂治疗。

     

    Abstract: Objective To evaluate the level of LDL-cholesterol(LDL-C) goal attainment and its influencing factors in patients after PCI. Methods A total of 133 patients who underwent coronary artery stenting in the First People's Hospital of Jingzhou from December 2016 to November 2017 were included in our study. According to the review of LDL-C, the patients were divided into achievement group(n=46) and non-achievement group(n=87). There were 36 males and 10 females in the achievement group with average age of(61.74±7.09) years, and 62 males and 25 females were included in the non-achievement group with average age of(62.11±9.22) years. Logistic regression analysis was performed to find the influencing factors of LDL-C goal attainment. Results Logistic regression analysis showed that sustained statins-taken history(OR, 0.43, P=0.005) and high treatment adherence(OR, 0.42, P=0.045) were the protective factors of LDL-C goal attainment, while overweight(OR, 1.31, P=0.040), more types of medication(OR, 3.70, P=0.001) were risk factors. Postoperative follow-up showed that Seattle Angia Questionnaire Scores in patients of achievement group were significantly higher than those of patients in non-achievement group(P< 0.001, respectively). Conclusion The study result suggests that sustained statins-taken history and high medication adherence are the protective factors of LDL-C goal attainment, while overweight and more types of medication are risk factors.

     

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