Abstract: Objective To compare the success rate of electromagnetic navigation bronchoscopy and conventional bronchoscopy for lung biopsy under local anesthesia. Methods Clinical data about 40 patients underwent lung lesions biopsy by electromagnetic navigation bronchoscope and 40 patients with lung lesions biopsy by conventional bronchoscope from March 2017 to May 2018 in the First Medical Center of Chinese PLA General Hospital were retrospectively analyzed. Results There was no significant difference in gender and age between two groups(male, 25 vs 20; age, 58.21±15.67 years vs 58.43±8.44 years, P> 0.05,respectively). The diameter of pulmonary lesions in electromagnetic navigation group was(2.43±0.67) cm, and it was(4.00±1.83)cm in conventional bronchoscopy group with significant difference(P< 0.001). Under local anesthesia, the success rate of biopsy was 92.5% in electromagnetic navigation group, significantly higher than 75% in conventional bronchoscopy group(P=0.034). There was no adverse drug reactions and related complications in two groups. Conclusion Compared with conventional bronchoscopy,the success rate of electromagnetic navigation bronchoscopy under local anesthesia is higher. It is more effective in biopsy to lesions with small diameter, and close to the peripheral part of the lung.