Abstract: Objective To analyze clinical features of advanced lung cancer patients admitted to emergency department and risk factors of death within 3 months. Methods Clinical characteristics of 112 patients with advanced lung cancer admitted to the emergency department during the regular treatment from January 2016 to December 2018 were analyzed, and the risk factors of death were analyzed by univariate and multivariate regression. Results Of the 112 patients, 75(66.9%) cases were male and 37(33.1%) cases were female, with a median age of 67.2 years. There were 67 cases of adenocarcinoma(59.8%), 24 cases of squamous cell carcinoma(21.4%) and 21 cases of small cell lung cancer(18.8%). Pneumonia occurred in 69 cases(61.6%), dyspnea in 63 cases(56.3%), respiratory failure in 63 cases(56.3%), consciousness disturbance in 26 cases(23.2%), hemoptysis in 13 cases(11.3%), epilepsy in 8 cases(7.1%), hemorrhage in 6 cases(5.4%), radioactive pneumonia in 6 cases(5.4%), and superior vena cava syndrome in 4 cases(3.6%). The mortality rate was 64.3% within 3 months. Univariate analysis showed that respiratory failure, white blood cell count, blood lactic acid, interleukin-6, D-dimer, and albumin were associated with the mortality within 3 months after emergency admission in patients with advanced lung cancer(P< 0.05). Multivariate logistic regression analysis showed that blood lactic acid(OR, 1.624; P=0.024), albumin(OR, 0.839; P=0.001) and respiratory failure(OR, 2.972; P=0.013) were independent factors for death within 3 months after emergency admission(P< 0.05). Conclusion Patients with advanced lung cancer admitted to the emergency department have a poor prognosis and a high mortality rate within 3 months. Hyperlactic acidemia, hypoproteinemia and respiratory failure are independent risk factors for death within 3 months.