Abstract: Objective To discuss the surgical treatment outcomes of gastrointestinal stromal tumor and clinicopathological factors affecting the prognosis. Methods Clinicopathological data of 102 patients with gastrointestinal stromal tumors from January 2010 to May 2013 in Ningbo First Hospital were retrospectively analyzed. The patients were followed up, and the outcomes of treatment and factors affecting the prognosis were analyzed. Results The gastrointestinal stromal tumor were completely excised in all cases, and they were followed up for 1-88(median, 59.5) months. Thirteen patients died, 1 case had metastasis, with the median overall survival of 59 months, and the 3-and 5-year survival rates were 94.9% and 86.3%. Univariate analysis showed that age, tumor site, tumor size, mitotic count, modified NIH risk stratification and whether received imatinib treatment after surgery were associated with the long-term prognosis. Multivariate analysis showed that age(HR=21.448; P=0.021), tumor size(HR=0.060; P=0.029), mitotic count(HR=0.008; P=0.034), modified NIH risk stratification(HR=0.213; P=0.044) were independent influencing factors for long term overall survival of patients with gastrointestinal stromal tumors. Conclusion Surgery is an effective method in treatment of gastrointestinal stromal tumors. Age, tumor size, mitotic count and modified NIH classification are independent influencing factors affecting the prognosis.