Abstract: Scientific research database is an important tool for clinicians to collect and collate data. At present, manual data collection is still the main method with many problems, such as heavy workload, low efficiency, high error rate, and difficulties in data sharing and utilization after collection and collation. Facing the diverse needs of scientific research from medical staff under big data environment, our hospital has built an integrated disease database platform for scientific research, which has achieved the function including visualization, personalized customization and template management of case report form (CRF), data integration, automation and importing batch, and data safety management, so as to provide assistance for clinicians to carry out clinical research with high quality and efficiency.