Abstract: Objective To compare the perioperative indicators and short-term outcomes of laparoscopic versus open liver resection for tumors in segment Ⅶ and Ⅷ. Methods Clinical data about 32 patients (18 benign and 14 malignant tumors) aged 36-68 years who received laparoscopic liver resection (LLR group) and 48 patients (14 benign and 34 malignant tumors) aged 26-73 years who received open liver resection (OLR group) in our hospital from January 2015 to January 2018 were retrospectively collected and analyzed,and their perioperative and short-term outcomes were compared. Results There was no difference in operating time,time of Pringle maneuver,blood transfusion rate,and postoperative morbidity between the two groups (P>0.05).However,LLR group had obvious advantages in intraoperative blood loss (158.57 ml vs 428.70 ml),time to passing gas (2.55 days vs 3.14 days),time to removing the drainage (3.36 days vs 5.05 days),postoperative hospital stay (6.21 days vs 9.78 days),time to taking food (1.50 days vs 2.30 days),and liver functions than those in OLR group (all P<0.05).During the postoperative follow-up,there was no significant difference between patients with malignant tumor in the two groups in the postoperative recurrence rate (LLR:3.1%;OLR:0.4%) and the survival rate (100% in both groups) at 1 year after operation (P>0.05). Conclusion There is no difference in short-term outcomes between laparoscopic and open liver resection for the radical treatment of malignant tumors.However,laparoscopic liver resection has the advantages of minimally invasive and rapid recovery,which can be carried out routinely.