北京地区90例新型冠状病毒肺炎患者临床特征分析

高文; 杨雪; 郑小勤; 苏璇; 窦爱华; 惠威; 刘梅; 徐斌

doi:10.3969/j.issn.2095-5227.2020.03.002

北京地区90例新型冠状病毒肺炎患者临床特征分析

Clinical characteristics of 90 patients with COVID-19 hospitalized in a Grade-A hospital in Beijing

摘要

摘要:
目的分析北京地区新型冠状病毒肺炎患者的临床特征。
方法分析2020年1月- 2020年2月于北京佑安医院住院并经中国疾控中心确诊的90例COVID-19患者的临床资料，按国家卫生健康委员会办公厅对新型冠状病毒感染的肺炎诊疗方案(试行第六版)进行临床分型诊断，观察不同临床分型患者临床表现、影像学及实验室指标特点。
结果男性43例(47%)，女性47例(53%); 年龄1 ~ 94(51.7±18.6)岁。其中轻型2例(2.22%)，普通型55例(61.11%)，重型22例(24.44%)，危重型11例(12.22%)。中位潜伏期为3(1 ~ 17) d; 住院时间平均值为12.78 d。有湖北人员接触史或湖北旅居史54例(60%)，聚集性发病为58例(64.4%)。与临床危重型患者相比，轻型和普通型患者的白细胞计数(white blood cell count，WBC)、C反应蛋白(C-reactive protein，CRP)、直接胆红素(direct bilirubin，DBIL)、估算肾小球滤过率(estimated glomerular filtration rate，eGFR)、肌酸激酶同工酶(creatine kinase isoenzyme，CK-MB)、肌红蛋白(myoglobin，MYO)、肌钙蛋白I(troponin I，TNI)等参数均显示出统计学差异。
结论新型冠状肺炎多呈聚集性发病，普通型居多。临床分型有助于更准确地判断病情及预后，指导临床治疗。

Abstract:
Objective To analyze the clinical characteristics of COVID-19, and provide evidence for its diagnosis and treatment.
Methods Clinical data about 90 patients with COVID-19 admitted to Beijing You'an Hospital confirmed by the Chinese Center for Disease Control and Prevention from January to February in 2020 were analyzed. According to the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (trial 6 version) edited by the National Health Committee General Office, the COVID -19 patients were classified into different clinical types, and their clinical features, radiological characteristics and laboratory indicators were observed.
Results Forty-three cases (47%) were male and 47 cases (53%) were female. The age ranged from 1 to 94 years, with average age of (51.7±18.6) years. Mild type was found in 2 cases (2.22%), moderate type in 55 cases (61.11%), severe type in 22 cases (24.44%), and critically ill type in 11 cases (12.22%). The median of incubation period was 3 days (range, 1 to 17 days). The average length of hospital stay was 12.78 days. There were 54 cases (60%) with contact history or travel history to Hubei province, and 58 cases (64.4%) were infected because of gathering. There were statistically significant differences in white blood cell count (WBC), c-reactive protein (CRP), direct bilirubin (DBIL), estimated glomerular filtration rate (eGFR), creatine kinase isoenzyme (CK-MB), myoglobin (MYO), troponin I (TNI) and other parameters between mild/moderate type patients and critically ill patients.
Conclusion The moderate type accounts for a large proportion of COVID -19 patients. Clinical classification is helpful to judge the condition and prognosis more accurately and guide the clinical treatment.

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