Abstract: Objective To explore the value of chest CT score and hs-CRP in the staging diagnosis of COVID-19. Methods Clinical data about 65 cases with confirmed COVID-19 admitted to our hospital from January to February in 2020 were retrospectively analyzed.They were divided into four groups according to the disease progression:stage 1 (0-3 days),stage 2 (4-7 days),stage 3 (8-14 days) and stage 4 (15-21 days).According to the clinical classification,the patients were divided into two groups:mild/moderate group and severe/critically ill group.CT score was calculated according to the extent of chest CT lesions,and the correlation between CT score and hs-CRP was analyzed. Results Of the 65 cases,there were 33 males and 32 females,with an average age of 52.77±13.95 years.According to the disease progression,the CT score (stage 3 vs stage 1,stage 2,and stage 4:11.27±2.02 vs 2.79±1.25,6.40±1.32,2.50±1.42) and hs-CRP value (stage 3 vs stage 1,stage 2,and stage 4:81.61±63.46 mg/L vs 8.94±6.16 mg/L,41.78±19.79 mg/L,7.10±7.74 mg/L) in stage 3 were significantly higher than those in the other three stages (all P<0.05).According to clinical classification,the CT score (12.05±1.75 vs 4.11±2.25) and serum hs-CRP value (82.17±64.97 mg/L vs 25.01±21.77 mg/L) were higher in severe/critically ill patients than in mild/moderate patients (P<0.05).There was a positive correlation between CT score and hs-CRP value (r=0.76,P=0.001). Conclusion CT score combined with hs-CRP plays an important role in the diagnosis and dynamic evaluation of COVID-19.