Abstract: Objective To explore the effects of resistance training method under the guidance of muscle oxygen monitoring on lower limb strength and motor function in stroke patients with hemiplegia. Methods From March to September in 2019,30 patients in the rehabilitation department of the first medical center of Chinese PLA General Hospital who needed to improve the muscle strength of the affected lower limbs during the recovery period of stroke were randomly divided into routine group (n=15) and myo-oxygenation group (n=15).Both groups received the routine rehabilitation treatment mainly based on Bobath neurotherapy.On this basis,the routine group used MRS-FS to carry out the standardized leg semi supine squat progressive resistance training;the muscle oxygen group carried out the same resistance training under the guidance of the oxygen saturation curve of the affected lateral femoral muscle for 4 weeks,5 times a week,15-20 minutes each time.Before and after the training,the isokinetic flexion and extension of the knee,the active and passive joint activity of the knee,"stand to walk" time,10 meter walking time,Fugl Meyer lower extremity function score,the modified Ashworth scale and other clinical evaluation tests were carried out. Results There was no significant difference in general data and clinical characteristics between the two groups before training (all P>0.05).After 4 weeks of training,in both of the two groups,there were significant improvements in peak torque (PT),peak torque/body weight (PT/BW),average peak torque (APT) of keen extensors at 60°/s,120°/s and 180°/s angular velocity,and the knee joint active mobility,flexion/extension (F/E) at 60°/s,walking ability,Fugl-Meyer score,MAS (all P<0.05),but no significant difference was found in passive activity indexes.Compared with the routine group,myo-oxygenation group had significant greater increase in PT,PT/BW and APT of the lower extensor knee muscle (all P<0.05),but the knee flexion strength and other indexes after training showed no intergroup difference (all P>0.05). Conclusion It may be beneficial to improve the local strength of lower limb in stroke patients with hemiplegia by resistance training under muscle oxygen monitoring.