Abstract: Objective To analyze the clinical distribution,drug resistance and homology of Elizabethkingia meningoseptica. Methods Clinical data about 44 patients infected with Elizabethkingia meningoseptica from April 2012 to December 2018 in our hospital were collected.The 44 bacteria strains were reidentified and their homology was analyzed by mass spectrometer.The drug resistance rate of Elizabethkingia meningoseptica to 12 kinds of drug was tested by broth microdilution method. Results The bacteria were mainly isolated from lower respiratory tract (accounted for 81.7%),and mainly distributed in the department of ICU,followed by department of respiratory and emergency department.The similarity of these strains was low.The resistance rates of these strains to amikacin,ciprofloxacin,sulfamethoxazole/trimethoprim and meropenem were higher than 80%,and the resistance rate of it was 100% to ceftazidime,cefepime and gentamicin.But the strains were 100% susceptible to minocycline. Conclusion Our clinical strains of Elizabethkingia meningoseptica possesses higher level of drug resistance and minocycline is the most susceptible antibiotic for therapy choice.These strains are heterogenous,and do not cause outbreak of epidemics in our hospital.