Abstract: Megaprosthesis replacement is the most common way to reconstruct bone defects after tumor resection.Perimegaprosthetic infection (PMI) is one of the leading causes resulting in prosthesis failure.Amputation has been a common way to treat PMI in the past.Although the infection can be well controlled,the postoperative function is poor,thus bringing heavy psychological burden to patients.The pervasive methods of limb salvage treatment include debridement,antibiotics,irrigation and implant retention (DAIR),single-stage revision,two-stage revision,etc.DAIR and single-stage revision have the advantages of shorter operating time and better postoperative function,but the incidence of reinfection is quite high.On the contrary,the two-stage revision is much better than the single-stage revision in infection control despite more operations,longer hospital stay and poorer postoperative function.This article aims to review the etiology,diagnosis,prevention and treatment of PMI.