老年患者锥形套囊气管导管声门下分泌物引流量影响因素分析

Influencing factors for volume of subglottic secretion drainage in elderly patients using tapered-cuff endotracheal tube

  • 摘要:
      背景  锥形套囊气管导管的声门下吸引效果是其预防呼吸机相关性肺炎(ventilator-associated pneumonia,VAP)的关键,而声门下分泌物引流量是衡量吸引效果的直接指标,引流量较少提示声门下吸引不彻底或气囊上滞留物下移,其影响因素多样,目前关于老年患者的研究较少。
      目的  分析导致老年患者锥形套囊气管导管声门下分泌物引流量较少的因素,为锥形套囊气管导管的规范使用提供依据。
      方法  选取解放军总医院第一医学中心和第二医学中心2018年1月- 2019年12月使用锥形套囊可吸引气管导管且年龄≥ 65岁的患者,记录声门下分泌物吸引的引流量,以中位数为截点分组,比较引流量较少组和引流量正常组的相关指标。
      结果  共计纳入63例患者,其中男性59例,女性4例,年龄65~103(84.87 ± 9.76)岁。使用锥形套囊气管套管时间为21~132(74.33 ± 34.59) d,共进行441次吸引,声门下分泌物引流量为0~8(3.69 ± 1.43) mL,中位数4 mL。单因素分析显示声门下分泌物引流量较少与分泌物黏稠度、卧位、原发病及患者性别有明显相关性(P<0.05)。多因素分析显示,分泌物黏稠度为凝胶样、原发病为肺部感染和男性是声门下分泌物引流量较少的独立影响因素(OR>1,P<0.05)。
      结论  使用锥形套囊可吸引气管导管的老年患者,原发病为肺部感染、男性、声门下分泌物为凝胶样与引流量较少相关。凝胶样分泌物需要进行声门下冲洗彻底清除。

     

    Abstract:
      Background  The effect of subglottic suction with tapered-cuff endotracheal tube is the key to the prevention of ventilator-associated pneumonia, and the volume of subglottic secretion drainage is an important index for the effect of suction. Low drainage volume may indicate incomplete subglottic suction or subglottic secretion leaking into the trachea, but the influencing factors are various. At present, there are few studies on elderly patients with this disease.
      Objective  To investigate the influencing factors for low volume of subglottic secretion drainage in elderly patients using tapered-cuff endotracheal tube, and provide evidence for standard use of tapered-cuff endotracheal tube.
      Methods  The patients, aged > 65 years, who used the tapered-cuff endotracheal tube in our hospital from January 2018 to December 2019 were included, and the volume of subglottic secretion drainage was recorded. The patients were divided into low drainage group and normal drainage group based on median drainage volume, and related indices were compared between the two groups.
      Results  A total of 63 elderly patients were enrolled, with 59 male patients and 4 female patients aged from 65-103 (84.87 ± 9.76) years. The duration of use of tapered-cuff endotracheal tube was 21-132 (74.33 ± 34.59) days; suction was performed 441 times in total, and the volume of subglottic secretion drainage was 0-8 (3.69 ± 1.43) mL, with a median of 4 ml. Univariate analysis showed that low volume of subglottic secretion drainage was significantly associated with secretion viscosity, supine position, primary disease and sex (P < 0.05), while multivariate analysis showed that gel-like secretion, a primary disease of pulmonary infection, and male sex were independent influencing factors for low volume of subglottic secretion drainage (odds ratio > 1, P < 0.05).
      Conclusion  For the elderly patients using tapered-cuff endotracheal tube, low drainage volume is associated with a primary disease of pulmonary infection, male sex, and gel-like subglottic secretion, which needs to be completely removed by subglottic irrigation.

     

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