Abstract:
Background Penetrating abdominal trauma is common in war, and in order to improve cure rate, it is necessary to close the wound as soon as possible to protect the abdominal organs.
Objective To develop a novel functional abdominal wall sealing dressing, which can meet the need for rapid hemostasis, defect closure and real-time monitoring of abdominal pressure in the emergency treatment of open abdominal wall injury.
Methods Thermoplastic polyurethane (TPU) nanofiber membrane was prepared by electrospinning and a TPU capacitive pressure sensor was assembled. Then, the TPU capacitive pressure sensor was assembled with chitosan hemostatic dressing by biological adhesive to prepare a functional abdominal wall sealing dressing. The dressing was tested in terms of in vitro pressure sensing performance, mechanical property, biocompatibility and hemostatic performance, and an animal model was established to test in vivo pressure sensing performance.
Results The elasticity of the dressing was better than that of the conventional medical dressing. In the in vitro test, it showed excellent pressure sensing performance, biocompatibility and hemostatic performance. In an open abdominal wall injury model, the intra-abdominal pressure could be monitored in real-time by the functional dressing.
Conclusion In this study, a capacitive pressure sensor is embedded into chitosan hemostatic dressing to enable the real-time monitoring of intra-abdominal pressure, and therefore, it is expected to be used in the emergency treatment of penetrating abdominal injury.
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