Abstract:
Background Major depressive disorder (MDD) is a common mental disorder with complex etiology and pathophysiology. However, the molecular mechanism of MDD has not been fully elucidated. Currently, a few studies suggest that lipid metabolism may be related to the occurrence and development of MDD.
Objective To explore the correlation of MDD with serum lipid and related proteins in adults.
Methods From February 2019 to September 2020, 138 patients with MDD admitted to Beijing Huilongguan Hospital and 86 healthy controls were included. Venous blood samples were collected to detect biochemical indexes such as blood lipids by enzymatic method.
Results Compared with the control group, the patients with MDD had lower levels of ApoA1 (1.39 ± 0.34 g/L vs 1.71 ± 0.31 g/L, P=0.000) and higher levels of HDL-C (1.40 ± 0.38 mmol/L vs 1.31 ± 0.28 mmol/L, P=0.008). Univariate analysis of depression-related factors showed that BMI, smoking history, education years and ApoA1 levels were significantly correlated with MDD (all P＜0.05). Multiple logistic regression analysis showed that the risk of MDD at middle (1.47 ± 0.09 g/L) and high levels (1.92 ± 0.27 g/L) of ApoA1 was 0.99 times lower than that at low levels (1.14 ± 0.11 g/L) of ApoA1 (OR=0.01, 95% CI: 0.00-0.07, P＜0.0001, respectively). After adjusting the related risk factors, there was no obvious change in the results. The risk of MDD in middle-level and high-level ApoA1 groups was still lower than that in low-level ApoA1 group by 0.94 times and 0.89 times, respectively (OR=0.06, 95% CI: 0.01-0.42, P=0.0048; OR=0.11, 95% CI: 0.02-0.80, P=0.0288). But the level of HDL-C had no significant difference in the risk of MDD (P＜0.05).
Conclusion The level of ApoA1 in patients with MDD is significantly lower than that in the control group. ApoA1 may be an independent risk factor for MDD, which still needs to be confirmed by more studies.
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