眼眶减压联合斜视手术治疗甲状腺相关眼病的疗效分析

Orbital decompression combined with strabismus surgery in treatment of thyroid-associated ophthalmopathy

  • 摘要:
      背景  甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)既往手术治疗多选用分步法,即眼眶减压、斜视矫正、眼睑修复,近年部分研究发现联合手术治疗能够获得良好的手术效果,缩短恢复期。
      目的  观察眼眶减压手术联合斜视矫正手术对TAO的治疗效果。
      方法  选取2021年1月- 2022年1月在解放军总医院第三医学中心眼科医学部眼眶病外科因TAO及限制性斜视行均衡眼眶减压手术的病例,分析指标包括最佳矫正视力、眼球突出度、眼位、复视等情况。
      结果  共计17例(20眼)纳入分析,其中男性13例,女性4例,平均年龄(50.00 ± 8.35)岁。眼眶均衡减压手术能够有效降低TAO患者眼球突出度17.75 ± 0.42) mm vs (22.40 ± 0.42) mm,P<0.001,减轻视神经压迫,提高视力(LogMAR视力0.22 ± 0.06 vs 0.52 ± 0.09,P=0.031)。17眼行斜视矫正术后有效缓解复视(手术成功率85%)。手术失败的3眼分析原因可能为年龄较小、双眼眼球突出度差异小、眼眶减压效果差(术前术后眼球突出度差异小)及双眼均存在限制性斜视。
      结论  眼眶均衡减压手术联合斜视矫正手术对TAO患者疗效佳,是治疗TAO合并限制性斜视的有效手术方案。

     

    Abstract:
      Background  The surgical treatment of thyroid-associated ophthalmopathy (TAO) is carried out by three steps nowadays, that is, orbital decompression, strabismus correction and eyelid surgery. Recent studies have found that orbital decompression combined with strabismus correction or eyelid surgery can shorten the recovery period and has good results as well.
      Objective  To observe the therapeutic effect of orbital decompression surgery combined with strabismus correction surgery on TAO.
      Methods  Clinical data about patients with TAO and restrictive strabismus who accepted balanced orbital decompression together with strabismus correction surgery from January 2021 to January 2022 in our center were collected. Main outcome measures included best corrected vision acuity, proptosis, ocular position and ocular movement, diplopia.
      Results  Totally 17 TAO patients (20 eyes) were enrolled, with 13 males and 4 females, and an average age of 50 ± 8.35 years. Balanced orbital decompression surgery effectively reduced the proptosis in TAO patients (17.75 ± 0.42 mm vs 22.4 ± 0.42 mm, P<0.001), alleviated optic nerve compression and improved visual acuity (LogMAR: 0.22 ± 0.06 vs 0.52 ± 0.09, P =0.031). Strabismus correction surgery effectively alleviated diplopia in 17 eyes, with success rate of 85%. For the 3 failed eyes, young age, smaller interocular exophthalmos difference, unsatisfactory orbital decompression outcome (smaller differences in preoperative and postoperative proptosis), and restrictive strabismus of both eyes might be the adverse factors.
      Conclusion   Balanced orbital decompression combined with strabismus correction surgery shows satisfactory outcomes for TAO patients, which can be an effective surgical solution for the treatment of TAO with restrictive strabismus.

     

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