云南省大理州50岁及以上HIV/AIDS患者生存状况分析

杨丽芬; 黄丽花; 陈志娟; 陆梅泾; 尹顺珠

doi:10.3969/j.issn.2095-5227.2023.02.006

云南省大理州50岁及以上HIV/AIDS患者生存状况分析

Analysis of survival status of HIV/AIDS patients over 50 years old in Dali Prefecture

摘要

摘要:
背景云南省大理州1997年首次报告50岁及以上人类免疫缺陷病毒(human immunodeficiency virus，HIV)感染者/艾滋病(acquired immunodeficiency syndrome，AIDS)患者(简称HIV/AIDS患者)，2010年以后50岁及以上HIV/AIDS患者报告数呈现明显上升趋势。2017年公布的《中国遏制与防治艾滋病“十三五”行动计划》中，已正式将老年人作为艾滋病防治的重点人群之一。
目的分析大理州50岁及以上HIV/AIDS患者的生存状况。
方法对1997 - 2018年报告的50岁及以上HIV/AIDS患者，运用寿命表法计算生存率，运用Cox回归分析生存的影响因素。
结果大理州2 019例50岁及以上HIV/AIDS患者的中位生存时间为8.33年(95% CI：7.75 ∼ 9.33)。寿命表法分析结果显示确诊后1年、5年、10年的生存率分别为74.76%、56.26%、40.29%。Cox回归分析结果显示50岁及以上HIV/AIDS患者男性死亡风险是女性的1.74倍(95% CI：1.43 ∼ 2.12)；未抗病毒治疗患者的死亡风险是抗病毒治疗患者的9.32倍(95% CI：7.86 ∼ 11.05)；2010年以后报告患者死亡风险是2010年及以前报告患者的0.62倍(95% CI：0.52 ∼ 0.74)。
结论应加强对50岁及以上中老年人群的艾滋病防治工作，早检测、早发现、早治疗是此类人群艾滋病防治的重点措施。

Abstract:
Background HIV/AIDS patients aged 50 years and above are first reported in Dali prefecture in 1997, and the number of HIV/AIDS patients aged 50 years and above shows an obvious upward trend after 2010. In China's 13th Five-Year Action Plan for HIV/AIDS prevention and control released in 2017, the elderly have been officially identified as one of the key groups in HIV/AIDS prevention and control.
Objective To analyze the survival status of HIV/AIDS patients aged over 50 years in Dali Prefecture.
Methods Life table method was applied to analyze the survival rate of HIV/AIDS patients over 50 years from 1997 to 2018. Cox regression was used to analyze the influencing factors of survival time.
Results The median survival time of 2 019 HIV/AIDS patients was 8.33 years (95% CI: 7.75 - 9.33). Life table analysis showed that the 1-year, 5-year and 10-year survival rates were 74.76%, 56.26% and 40.29%, respectively. Cox regression analysis showed that men over 50 years old were 1.74 times (95% CI: 1.43 - 2.12) more likely to die of HIV/AIDS than women, while patients without antiviral treatment were 9.32 times (95% CI: 7.86 - 11.05) more likely to die of HIV/AIDS. The risk of death after 2010 was 0.62 times (95% CI: 0.52 - 0.74) of that before 2010.
Conclusion It is necessary to strengthen the prevention and treatment of AIDS among the middle-aged and elderly people aged 50 years and above. Early detection and treatment are the key measures for AIDS prevention and treatment.

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