Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disease with a long course and high disability rate, and its pathogenesis and etiology are still unclear. DNA methylation, as one of the important epigenetic modifications, has become a hot topic of research in the pathogenesis of PD and other neurodegenerative diseases in recent years. In this paper, we review the relevance of DNA methylation regulation to PD genome-wide, susceptibility gene methylation regulation, mitochondrial DNA methylation regulation, and environmental factors, in order to provide theoretical references for studying the pathogenesis of PD and developing new therapeutic targets for PD.