Abstract: Immunotherapy has been widely used in clinical practice, and it has achieved remarkable effect on the treatment of tumors in different organs. However, as a double-edged sword, immunotherapy induces various inflammatory side effects, which not only weakens the efficacy of immunotherapy, leads to the suspension of immunotherapy, but also limits the development of immuno-therapy and the combination of traditional radiotherapy and chemotherapy. Therefore, based on the important role of inflammation in all stages of tumor genesis, development and treatment, targeted inflammatory therapy combined with immunotherapy will reduce inflammatory side effects of immunotherapy, and improve the efficacy of a new generation of immunotherapy, providing new possibilities for long-term, multi-level tumor treatments. In this article, we will introduce several major immunotherapy-related inflammatory side effects and the corresponding mechanisms to explore the latest anti-inflammatory strategies for reducing inflammatory side effects, so as to avoid immunotherapy defects and ultimately maximize the role of immunotherapy.