Abstract: Objective To study the therapeutic effect of colpocleisis on urinary symtpoms in patients with pelvic organ prolapse（POP）Methods From October 2005 to February 2010,60 patients with stagesⅢandⅣPOP diagnosed with POP-Q system underwent total and partial colpocleisis.Outcomes of the patients were compared using the urinary distress inventory（UDI-6）,pelvic organ prolapse distress inventory（POPDI-6） and urinary impact questionnaire（UIQ-7）,and pelvic organ prolapse impact questionnaire（POPIQ-7） 2 months,6 months and 1 year respectively before and after operationResults The patients were followed up for 2 months,6 months and 1 year respectively after operation,with a follow-up rate of 93%（56/60）,88%（53/60） and 87%（52/60） respectively.The obstructive urinary symtpoms disappeared completely 2 months after operation.The other symptoms such as frequency and urgency of urination as well as stress incontinence improved significantly 2 months after operation and maintained for 1 year.The mean score for urinary symtpoms and quality of life of the patients was significantly higher after operation than before operation（P=0.000 0）Conclusion Colpocleisis can effectively improve the urinary symtpoms and quality of life of patients with POP.