Abstract: Objective To evaluate the effect and safety of pamidronate disodium in treatment of hypercalcemia due to primary hyperparathyroidism（PHPT）. Methods Blood calcium,creatinine,white blood cells and adverse effects of pamidronate disodium in 8 patients with hypercalcemia due to PHPT 14 days after treatment with pamidronate disodium in Chinese PLA Hospital from 2006 to 2010 were retrospectively analyzed. Results The average serum calcium level decreased to 3.58mmol/L from 4.02mmol/L 1 day after treatment with pamidronate disodium and the best time of pamidronate disodium in reducing the serum calcium level was 5-7 days with a maximal serum calcium decease of 40.0%.Among the 8 patients,the serum calcium level returned to normal in 5 patients.Body temperature was increased in 6 patients and reached to 39.5℃,which occurred within 24h after treatment with pamidronate disodium and continued for 2-5 days,and then decreased after expectant treatment.The number of white blood cells decreased to less than 4.0×10⁹/L in 1 patient,the blood creatinine level was mildly increased in 3 patients,and the pain of knee joints,manual intephalangeal joints,and muscle occurred in 2 patients. Conclusion Pamidronate disodium can be used in treatment of hypercalcemia caused by PHPT due to its rapid and long-acting effect,and mild adverse effects.