磷脂酶A<sub>2</sub>阻断剂对再灌注损伤后一氧化氮的影响及其意义

磷脂酶A₂阻断剂对再灌注损伤后一氧化氮的影响及其意义

摘要: 采用家兔失血性休克/再灌注模型(S/R),观察损伤后血浆中一氧化氮(NO)终代谢产物的改变及磷脂酶A_2阻断剂氯喹及其同类合成药磷酸萘酚喹、抗氧化剂黄芪酮治疗对其的影响。结果表明S/R后24h内血浆含量逐渐下降同血pH值及二氧化碳结合力TCO₂下降有正相关;应用磷脂酶A_2阻断剂和抗氧化剂可在一定程度上阻断的减少,且对维持体内酸碱平衡有一定作用。

Abstract: The changes of plasma nitric oxide metabolites- were observed after hemorrhagic shock/reperfu-sion injury （S/R）in rabbits.The results showed that the level was positively correlated with the de-crease of TCO₂ and pH values after S/R 24 h,and phosphilipase A₂ inhibitor chloroquine, ME8101 as well asantioxidant（TFA）could be used to block the decrease of nitric oxide and maintain the acid-base balance in vi-vo.