国内首例非亲缘供者外周血造血干细胞移植治疗重型再生障碍性贫血

靖彧; 高春记; 达万明; 汤春静

国内首例非亲缘供者外周血造血干细胞移植治疗重型再生障碍性贫血

First case of unrelated donor allogeneic peripheral blood stem cell transplantation in the treatment of severe aplastic anemia in China

摘要

摘要: 目的: 探讨非亲缘供者外周血造血干细胞移植(UD-PBSCT)治疗重型再生障碍性贫血(SAA)的可行性。方法: 采用HLA-A 1个位点亚型不相合非亲缘供者的外周血造血干细胞治疗1例病程6年的SAA患者。预处理方案为环磷酰胺、足叶乙甙和抗人胸腺球蛋白,以霉酚酸酯、环孢菌素A、CD25单克隆抗体加短疗程的甲氨喋呤预防移植物抗宿主病(GVHD)。结果: 移植后22 d中性粒细胞达到0.998×10⁹/L,33 d血小板计数≥20×10⁹/L,50 d血小板升至52×10⁹/L,61 d血红蛋白升至104 g/L,无GVHD发生,移植后无病存活时间已达8个月。结论: UD-PBSCT可以使SAA患者短期内获得造血重建,可以作为治疗的选择。

Abstract: Objective: To investigate efficacy of unrelated donor allogeneic peripheral blood stem cell transplantation（UD-PBSCT） in treatment of severe aplastic anemia（SAA）.Methods: A 21-year-old Chinese woman had been suffering from SAA for 6 years.We did not find any HLAmatched related donor for the patient.The patient was treated with PBSCT from a HLA-A-1-allele-mismatched unrelated donor with cyclophosphamide,etoposide and antithymocyte globulin for conditioning.Mycophenolate mofetil,cyclosporin A,CD25 antibody and short-term methotraxate were administered as graft versus host disease（GVHD） prophylaxis.Results: The absolute neutrophil count of 0.998 ×10⁹/L was achieved at 22^nd day,the platelet count ≥20 ×10⁹/L at 33^rdday,the platelet counted to 52×10⁹/L at 50^thday,the hemoglobin counted to 104g/L at 61^st day.Disease-free survival without GVHD was 8 months.Conclusion: UD-PBSCT may be considered as a choice when hematopoietic stem cell transplantation is needed for SAA patients.

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