Abstract: Objective To study the clinical manifestations,operation,and prognosis of senile patients with gastric cancer. Methods A total of 209 patients with gastric cancer admitted to our department were divided into senile group（≥65 years） and non-senile group,and their clinical data were analyzed and compared. Results Gastric cancer was diagnosed in 63.2% of the patients.The percentage of asymptomatic patients was significantly higher in senile group than in non-senile group（23.5% vs 16.9%,P＜0.05）.The percentage of coexistent diseases was significantly higher in senile group than in non-senile group（81.8% vs 64.9%,P＜0.05）.The surgical resection rate,radical resection rate,perioperative complication rate and mortality were 90.9%,73.5%,14.4% and 3.0% in senile group,and 97.4%,89.6%,7.8% and 0% in non-senile group（P＜0.05）.No significant difference was observed in 5-year survival rate between the two groups（59.7% vs 61.1%,P＞0.05）.Multivariate analysis showed that TNM stage and radical surgery degree were the independent factors for the prognosis of gastric cancer patients（P＜0.05）. Conclusion Asymptomatic gastric cancer and coexistent diseases are commonly found in senile gastric cancer patients.The operation risk is greater in senile gastric cancer patients than in non-senile gastric cancer patients.There is no significant difference in prognosis between senile and non-senile gastric cancer patients.TNM stage and radical surgery degree are related with the prognosis of gastric cancer patients.