Abstract:
Objective: In order to evaluate the toxicity of phosphate produced as phosphorus burns occurred.
Methods: The dosage of phosphate caused 50% and 100% death (D50 and D100) were determined by subcutaneous injection of phosphate at different concentrations. According to the level of residual phosphorus within wounds following standard phosphor burns, rat models of phosphate burn were made by contacting with 45% phosphate solution for 30 sec. The mortalities of rats in phosphate burn group(Ⅰ) were compared with other groups including phosphor burn(Ⅱ), gasoline burn(Ⅲ) and hot water burn(Ⅳ).
Results: The D50 and D100 of phosphate in rats were 110 and 150mg respectively.The mortalities of rats in Ⅰ、Ⅱgroups were similar (about 60%), but significanhan Ⅲ、Ⅳ groups.
Conclusion: While burning phosphor causes thermal injur to skin, there produces quite amounts of phosphate,which likely leads to phosphate intoxication.