Abstract: The immeditate-type of allergic asthma animal model was established in sensitized guinea pigs by inhalation with ovalbumin. Respiratory impedance（Zrs）,activity of Ca²⁺-ATPase in lung tissue,effect of anisodamine （654-2） and verapamil on them were observed,The results sho-wed that Zrs in asthma group was increased than that in normal group （P＜0.01）,that activity of Ca²⁺-ATPase in lung tissue of asthma group was lower than that of normal group （P＜0.01）.The results suggested that decrease of Ca²⁺-ATPase activity in lung tissue may be an important factor in the pathogenesis of the allergic asthma. The increase of intracellular Ca²⁺may relate to decrease of Ga²⁺-ATPase activity.Anisodamine can increase Ca²⁺-ATPase activity.Verapamil has no effect on Ca²⁺-ATPase activity.