Abstract: Objective: To investigate the clinical features of the dead cases of severe acute respiratory syndrome （SARS） in order to give some advices to the diagnosis, treatment and prognosis of SARS. Methods: Data of epidemiology and laboratory examination of 5 dead SARS patients hospitalized from January to late April this year were retrospective analyzed. Results: The dead cases were all male, with average age of 49. There were average 9.6 days from disease incidence to hospitalization, 1.2days from hospitalization to identification, 14.4days from hospitalization to death, 22days from disease incidence to death. The total amount and percentage of the granulocytes increased greatly in all the 5 patients . The count and percentage of lymphocytes decreased, along with the hemoglobin decreasing in most of the patients. All the dead cases had higher glucose and lower albumin, except for ALT, AST, LDH, CK increasing and calcium decreasing, which were already reported. In most cases, multiple biochemistry items dropped significantly, such as TP, PA, etc, while the HHb increased greatly, accompanied with low P and Mg. Conclusion: Multiple items of laboratory examination will alter greatly in SARS patients. Constantly monitor of these items may benefit the diagnosis, treatment and prognosis of this disease.