Abstract: Objective To observe the therapeutic effect of integrated Traditional Chinese and Western Medicine on HBV-related liver failure. Methods Fifty-one patients with HBV-related chronic liver failure(HBV-CLF) and 52 patients with HBV-related acute on chronic liver failure(HBV-ACLF) were enrolled in this study.The HBV-CLF patients were divided into control group(n=24) and treatment group(n=27) The HBV-ACLF patients were divided into control group(n=26) and treatment group(n=26).The patients in control groups received routine liver protection,anti-virus and expectant treatment while those in treatment groups underwent routine liver protection,anti-virus and expectant treatment plus Traditional Chinese Medicine treatment for 4 weeks based on differentiation of their symptoms and signs. Results The effective rate of HBV-CLF was 63.0% and 54.3% respectively in treatment group and control group(P>0.05).The prothrombin activity(PTA) and the incidence of hepatic encephalopathy were lower in treatment group than in control group(P<0.05).The effective rate of HBV-ACLF was significantly higher in treatment group than in control group(80.8% vs 53.8%,P<0.05).The TBil,PTA,CHE and ALB levels and the incidence of ascites and hepatic encephalopathy were significantly lower in treatment group than in control group(P<0.05). Conclusion Integrated Traditional Chinese and Western Medicine can improve the therapeutic effect on HBV-ACLF.Although it cannot significantly improve the therapeutic effect on HBV-CLF,it plays a role in improving certain laboratory indications and in reducing complications of HBV-CLF.