早期胃癌术后复发的临床病理分析

Clinicopathological analysis for recurrence of early gastric cancer

  • 摘要: 目的: 评价早期胃癌(EGC)的术后复发率、复发类型、术后复发的预后因素和治疗。方法: 分析我院1995~2005年391例EGC接受根治性胃切除术及淋巴结清扫(D2)者的临床病理及随访资料。结果: 391例EGC中21例显示为5.4%的5年累积复发率。4例局部复发,2例腹膜复发,10例远处转移复发,5例残胃复发。多因素分析显示淋巴结转移与术后复发显著相关(P<0.001)。结论: 尽管EGC术后复发率较低,但具有淋巴结转移的EGC仍有较高的复发可能性,特别是>6个淋巴结阳性者,即使进行了根治性手术,仍应给予辅助化疗。

     

    Abstract: Objective: To evaluate the recurrence rate,the recurrence patterns and the prognostic factors for recurrence of early gastric cancer(EGC) as well as treatment results after recurrences.Methods: A retrospective search of 391 cases′ Clinicopathological results and follow-up records who were diagnosed as EGC and underwent curative operations(D2) during 1995-2005 in our hospital.Results: Of 391cases,21cases showed recurrences with a 5.4% 5-year cumulative recurrence rate.4 cases were locoregional recurrences,2 were peritoneal recurrences,10 were distant recurrences and 5 cases remnant gastric recurrences.Multivariate analysis revealed a significantly high correlation between positive lymph node metastasis and recurrence(P<0.001).Conclusion: Although the recurrence of ECG is very rare in general,ECG with lymph node metastasis has a higher possibility of recurring,especially with >6 positive lymph nodes,these patients should be considered as candidates for adjuvant chemotherapy.

     

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