涎腺腺样囊性癌的凝集素免疫组织化学分析

Lectin immunohistochemical study in adenoid cystic carcinoma of salivary gland

  • 摘要: 应用7种凝集素探针,观察了33例涎腺腺样囊性癌中的凝集素受体分布,并与正常涎腺组织进行比较。癌变组织中的PNA受体比正常组织明显增加,但UEA1受体却较正常组织减少。

     

    Abstract: Immunohistochemical distribution of seven lectins (ConA, SBA, DBA, RGA, WGA, UEA1, PNA) were evaluated in 33 cases of adenoid cystic carcinoma (AGC) arising in salivary glands. The results indicated that neoplastic ductal cells tended to mimic the glycoprotin synthesis of their normal conterparts. The distribution patterns of PNA and UEA1 were of special interest: much more PNA receptors were demonstrated in ACC than in normal salivary glared tissue, while UEA1 receptors were reduced in ACC as compared with normal tissue. Incresed PNA receptors may be a sign of malignent transformation in salivary gland tissue.

     

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