高血压病患者尸检主动脉与冠状动脉粥样硬化程度的相关性分析
Correlation analysis on the degrees of atherosclerosis between coronary artery and aorta at autopsy in patients with hypertension
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摘要: 近年来有学者采用B超的方法观查颈动脉、主动脉等大动脉粥样硬化状况,以间接了解冠状动脉粥样硬化(CAS)程度。为了解高血压患者主动脉粥样硬化(AAS)的程度能否反映CAS的程度,本文采用259例连续高血压病患者尸检资料,对AAS与CAS程度进行了相关分析。结果:259例高血压患者AAS发生率明显高于CAS发生率,二者分别为89.6%和83.8%(P<0.05),年龄组分析显示两者均随增龄而增长,但AAS较CAS增长更为明显,在70~79岁组及 ≥ 80岁组,上述两发生率分别为94.3%和86.4%(P<0.05),100%和86.8%(P<0.05),均有显著差异;总体AAS与CAS程度呈正相关(r=0.3633,P<0.01), ≥ 80岁组AAS与CAS程度无明显相关(r=0.08953,P>0.50)外,其余各组均呈显著正相关。本组高血压并冠心病者130例,其AAS与CAS程度呈显著正相关(r=0.2757,P<0.01),其中合并心肌梗死者69例,AAS与CAS程度无相关关系。AAS程度可以相应反映CAS程度,但在80岁以上高血压患者及高血压合并心肌梗死患者中,上述关系并不存在。Abstract: To evaluate the relation of the degrees of atherosclerosis between coronary atherosclerosis (CAS) and that of the aorta (AAS) in patients with hypertension, 259 continous autopsies data of hypertensive cases were analysised. Results: The incidence of AAS was significantly higher than that of CAS(89.6% vs 83.8%, P <0.05) though they were all increased with the grouth of age. There were significant differences between the incidence of AAS and CAS in the 70-79 and more than 80 years groups (94.3% vs 88.4%, and 100% vs 86.8%, P <0.05).And there was a significant positive correlation between these two kinds of lesions as a whole (r=0.3633, P <0.01). Among the age groups, there also showed a significant positive correlation between the degrees of AAS and CAS except the age group of more than 80. And also a significant positive correlation of the degrees of AAS and CAS (r=0.2751, P <0.01) revealed in 130 hypertensive patients complicated with coronary heart disease. Among them, 69 cases suffered from myocardial infarction,the correlation analysis of them showed a negtive result. Conclusion: The degree of AAS may reflect that of CAS correspondingly, but this correlation is not obvious in patients more than 80 year old or hypertension combined with myocardial infarction.
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