Abstract: Objective To summarize the clinical anesthesia experiences with 251 cases who underwent hepatobiliary and gastrointestinal surgery with da Vinci S robotics. Methods Anesthesia of 251 patients who underwent hepatobiliary and gastrointestinal surgery with da Vinci S robotics from January 2008 to June 2011 and its complications were analyzed and summarized. Results All patients were anesthetized and underwent surgery with robotics.The anesthesia time was 456.5±92.4min,the operation time was 414.6±83.6min,and the CO2 pneumoperitoneum time was 408.7±46.8min.The hemodynamics of patients was stable during operation.The PaCO2 was significantly higher after 180min of pneumoperitoneum than before operation（P＜0.05）,while the pH was significantly lower after 360min of pneumoperitoneum than before operation（P＜0.05）.Nine cases were transferred for laparotomy. Conclusion The hemodynamics of patients is stable during anesthesia of patients for abdominal operation with da vinci S robotics.The time of CO2 pneumoperitoneum is significantly longer than other surgical procedures,and thus often leading to acid-base disturbance.