西拉普利对大鼠缺氧性肺动脉高压治疗作用的实验研究

彭文鸿; 毛宝龄; 邹霞英; 李于功

西拉普利对大鼠缺氧性肺动脉高压治疗作用的实验研究

The therapeutic effects of cilazapril on hypoxic pulmonary hypertension in rats

摘要

摘要: 目的：观察西拉普利对大鼠缺氧性肺动脉高压的治疗作用。方法：应用血液动力学变化指标、循环内皮细胞（CEC）、一氧化氮（NO）、组织丙二醛（MDA）、血管紧张素转换酶（ACE）测定和电子显微镜病理学观察。结果：西拉普利治疗后，肺动脉平均压（2.85±0.22kPa）较安慰剂组（3.58±0.20kPa）显著下降，NO（24.00±4.21nmol/L）较安慰剂组（19.86±1.80nmol/L）显著升高（P＜0.01），肺组织ACE（38.70±4.62U）较安慰剂组ACE（45.17±4.56U）下降显著（P＜0.01），组织MDA（26.29±4.81nmol/mg）较安慰剂组（31.46±3.48nmol/mg）显著下降（P＜0.01），肺组织的病理学损伤减轻。结论：西拉普利可降低肺动脉高压，促进NO释放，减轻肺动脉内皮的病理损伤

Abstract: Objective: The experiment was designed to investigate the therapeutic effects of cilazapril on hypoxic pulmonary hypertension Methods: the hemodynamic variables, CEC and NO, tissue MDA and ACE determination and pathological observation by electron microscopy were performed and analysed. Results: Comparing both cilazapril and placebo groups, it showed that MPAP （2.85±0.22 kPa vs 3.58±0.20 kPa）,CEC（6.30±0.70/μl vs 7.63±0.50/μl）,ACE（38.70±4.62U vs 45.17±4.56 U） and MDA（26.29±4.81 nmol/mg vs 31.46±3.48 nmol/mg） decreased markedly（P＜0.01）,NO（24.00±4.21 mmol/L vs 19.86±1.80 mmol/L） rised obviously （P＜0.01）, as well as the pathological changes alleviated dramaticaly.Conclusion: the above date indicate that cilazapril may improve MPAP by reducing ACE, MDA and promoting NO productions and hence to alleviate the vascular endothelial injuries.

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