Abstract: The cardioprotective effects of mioflazine,a recently developed cardiovascular drug,against normothermic ischamia were evaluated in isolated rabbit hearts used in working mode.Pretreatment with 0.125mg/L of this drug improved recovery of cardiodynamic function（LVP,LVdp/dt, and CO）during postischamic reperfusion.
Morphological and cytochemical assessment of myocardium demonstrated that the ultrastructure of the sarculemma and its calcium binding capacity is remarkably well preserved in the drug treated animals.These results indicate a strong cardioprotective effect of mioflazine and the prevention of cellular Ca²⁺-overload.during postischamic reperfution.