脑室内中枢性神经细胞瘤

Central neurocytoma in intraventriclar

  • 摘要: 目的:研讨了17例位于脑室内的中枢性神经细胞瘤,以期提高对该病认识。方法:所有病例均行HE常规染色及NSE,Syn,NF,GFAP免疫组化染色,光镜下确诊。部分行电镜检查。结果:各例病变相似,肿瘤由大小较为一致的小圆细胞所组成,部分胞浆透亮,酷似少突胶质细胞瘤。免疫组化表达神经元的标记。电镜检查胞浆内可见神经内分泌颗粒。结论:结合文献及对患者随访,显示该肿瘤是起源于神经元、手术后呈良性经过的肿瘤。对手术难以切净的,或组织像呈间变者,可辅以放疗。

     

    Abstract: Objective:We discuss and reseach seventeen cases of central neurocytoma in intraventriclar,in order to improve recognition this disease.Methods:All cases stained with hematoxylin and eosin for routine histopathologic processing.For the immunohistochemical study,paraffin-embedded sections were stained with GFAP,NF,NSE and synaptophysin.All cases have made diagnosis by light microscopy.Electron microscopy have done in some cases.Results:Under microscopy:every case's pathologic changes was similar,the neoplasm was composed of uniform cells with round nuclei,some areas of small cells with perinuclear halos,which resembles an oligodendroglioma. An immunohistochemical examination revealed evidence of neuronal marker.Electron microscopy demonstrated of neuronal ultrastructural features,including neurosecretory granales.Conclusion:Compared with literature and follow-up examination,central neurocytoma is a neuronal lineage,and benign tumor with a favorable clinical course.Postoperative radiation therapy should be considered, especially in cases of subtotal tumor removal or of a histologically malignant form.

     

/

返回文章
返回