Abstract: objective: To learn the clinical and pathological characteristics of IgA nephropathy in patients with type 2 diabetic nephropathy.Methods: A total of 13 type 2 diabetic patients who had IgA nephropathy were studied retrospectively. The clinical and pathological features, the response to treatment were well observed. Results: diabetes patients combined with IgA nephropathy complicated with diabetes account for 46.3% of all non-diabetic renal disease（NDRD）in our hospital. Theses patients have different clinical features compared with diabetic nephropathy: 1.the courses of diabetes is less than 5 years; 2.certain degrees of hematuria; 3.hypertension is common; 4.tissue pathological changes are identical to IgA nephropathy, but the injury of vessels are severer than pure IgA nephropathy; 5.The patients of nephropathy syndrome with mild pathological changes are well responsible to corticosteroid. Conclusion: The renal diseases in diabetic patients are not all diabetic nephropathy, the most frequent disease entities are IgA nephropathy. The renal injury is due to IgA nephropathy, the vessel changes are severer. When clinical characters, pathological changes were considered completely and glycemia and hypertension were controlled strictly, the administration of corticosteroid or corticosteroid combined with cytotoxic drugs in nephropathy syndrome patients are safe and effective, the prognosis can be improved.