外周血CRP及IL-6检测对儿童脓毒症的诊断意义
Value of peripheral blood C-reactive protein and IL-6 levels for diagnosis of sepsis in children
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摘要: 目的 探讨外周血C反应蛋白(CRP)、白介素-6(IL-6)的测定在儿童脓毒症诊断中的价值。方法 选取脓毒症患儿90例,严重脓毒症13例,同时设立对照组,包括健康对照组20例,无全身感染反应性疾病组36例,测定外周血CRP、IL-6,分析其统计学意义。结果 脓毒症患儿CRP、IL-6与对照组比较差异有统计学意义(P<0.001)。受试者工作操作曲线(ROC)分析显示,CRP与IL-6的曲线下面积(AUC)为0.87,灵敏度80%,特异性分别为81%和77%。结论 CRP、IL-6检测对儿童脓毒症的早期诊断及疗效判定具有一定价值,CRP和IL-6可用于常规临床检测。Abstract: Objective To study the value of peripheral blood C-reactive protein（CRP） and IL6 levels for the diagnosis of sepsis in children. Methods Ninety children with sepsis served as a sepsis group,36 as a non-systematic infection group,13 as a severe sepsis group,and 20 healthy individuals as a control group.Peripheral blood CRP and IL–6 levels in 90 children with sepsis were measured and their statistical significance was analyzed. Results The CRP and IL-6 levels were higher in sepsis group than in control group（P＜0.001）.ROC analysis showed that the AUC of CRP and IL–6 was 0.87 with a sensitivity of 80% and a specificity of 81% and 77%,respectively. Conclusion Peripheral blood CRP and IL6 levels have a certain value for the early diagnosis of sepsis in children and can be used in routine diagnosis of sepsis.
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