Abstract: Objective: To observe the effectiveness of nitroprusside controlled hypotension and fluid replacement on perioperative circulation of pheochromocytoma. Methods: Before the tumor was removed，0.01% nitroprusside was used to maintain MAP with in 8 and 10 kPa in 12 patients undergoing elective pheochromocytoma ectomy，Meanwhile Ringer lactic solution and succinyl gelation were infused at the rate of 20～30ml·kg^-1·h^-1 respectively，Adjust infusion rate according to bleeding and urine output after urine output was more than 100ml h^-1.Monitoring: MAP，SpO2，ECG and urine output.Results: mean operation time: 210min，mean dosage of nitroprusside: 38.33mg，esmolol: 330mg，total infusion amount: 7250ml(117ml· kg^-1)，Urine output: 610ml，SpO2: 98%～100%，MAP and HR kept in desirable range with no operative complications. Conclusions: Nitroprusside controlled hypotension combined with prompt fluid replacement contribute more stable circulation and less operative complications in the operation of Pheochromocytoma ectomy.